Dimethyl Sulfoxide
Apexbio Technology LLC Aprepitant 170729-80-3 10mM (in 1mL DMSO)
Aprepitant (MK-0869) is a highly selective antagonist of the neurokinin-1 (NK-1) receptor functioning by competitively inhibiting substance P (SP) an undecapeptide belonging to the tachykinin family from activating NK-1 receptors Its binding affinity for human NK-1 receptors is indicated by a dissociation constant (Kd) of approximately 86 pM In cellular models overexpressing NK-1 receptors including glioma (GAMG) neuroblastoma (SKN-BE2 IC50 19 6 M IMR-32 IC50 27 7 M KELLY IC50 30 4 M) retinoblastoma (Y-79 IC50 23 M WERI-Rb-1 IC50 31 2 M) pancreatic cancer (PA-TU-8902 IC50 27 4 M CAPAN-1 IC50 22 7 M) and colon cancer (SW-403 IC50 30 5 M) aprepitant application has been reported to inhibit tumor cell proliferation in vitro
Apexbio Technology LLC Indirubin 479-41-4 10mM (in 1mL DMSO)
Indirubin (CAS 479-41-4) is a small molecule isolated from Danggui Longhui Wan a herbal medicine formulation It exerts anti-inflammatory effects primarily through the inhibition of interferon-gamma (IFN- ) production In vitro studies demonstrated that Indirubin suppresses IFN- secretion in human bone marrow mononuclear cells (HBL-38) and murine splenocytes without affecting cell proliferation In vivo administration of Indirubin reduced ear swelling in a mouse model of 2 4 6-trinitro-1-chlorobenzene (TNCB)-induced delayed-type hypersensitivity concomitant with decreased IFN- levels in lymphocyte cultures Indirubin is under clinical investigation for conditions such as psoriasis and acute promyelocytic leukemia
Apexbio Technology LLC Cathepsin S inhibitor 1373215-15-6 10mM (in 1mL DMSO)
Cathepsin S inhibitor (CAS 1373215-15-6) is a small-molecule inhibitor targeting the lysosomal cysteine protease Cathepsin S an enzyme critically involved in antigen processing and presentation By reversibly and selectively inhibiting Cathepsin S demonstrating notably less affinity for Cathepsin B this molecule impairs MHC class II-mediated antigen presentation resulting in selective immunosuppressive effects on T cells Consequently Cathepsin S inhibitor holds therapeutic potential for autoimmune and inflammatory conditions such as rheumatoid arthritis psoriasis and multiple sclerosis
Apexbio Technology LLC Tenofovir Disoproxil Fumarate 202138-50-9 10mM (in 1mL DMSO)
Tenofovir disoproxil fumarate is an antiviral nucleotide analog functioning as a nucleoside reverse transcriptase inhibitor (NRTI) Upon cellular uptake it undergoes enzymatic hydrolysis to form the active metabolite tenofovir subsequently phosphorylated to the diphosphate derivative This phosphorylated metabolite competitively inhibits HIV-1 reverse transcriptase and induces DNA chain termination In vitro studies using MT-2 cells and peripheral blood mononuclear cells (PBMC) have demonstrated suppression of HIV replication with reported EC50 values approximately 0 007 mol/L and 0 005 mol/L respectively This compound is routinely utilized in research investigating HIV replication mechanisms antiretroviral therapies and drug resistance profiles
Apexbio Technology LLC MI-77301 (SAR405838) 1303607-60-4 10mM (in 1mL DMSO)
MI-77301 (SAR405838 CAS 1303607-60-4) is a selective antagonist targeting the murine double minute 2 (MDM2) protein an E3 ubiquitin ligase responsible for negatively regulating tumor-suppressor p53 via ubiquitination and degradation By inhibiting the MDM2-p53 interaction (Ki 0 88 nM) MI-77301 stabilizes p53 elevates protein levels of p53 p21 and MDM2 and induces apoptosis Preclinical studies demonstrate selective growth inhibition in tumor cell lines harboring wild-type p53 (e g SJSA-1 RS4 11 LNCaP HCT-116) and potent tumor regressions in corresponding xenograft mouse models highlighting its utility for mechanistic studies and cancer therapeutic research
Apexbio Technology LLC Ondansetron hydrochloride dihydrate 103639-04-9 10mM (in 1mL DMSO)
Ondansetron hydrochloride dihydrate (CAS 103639-04-9) is a small molecule antagonist targeting the serotonin (5-HT3) receptor a ligand-gated ion channel prominent in the central and peripheral nervous systems Through blockade of 5-HT3 receptor signaling ondansetron inhibits serotonin-induced emetic responses Due to this mechanism it is widely utilized in biomedical research investigating serotonin-related signaling pathways and nausea mechanisms particularly in contexts involving chemotherapy-induced emesis
Apexbio Technology LLC Polydatin 27208-80-6 10mM (in 1mL DMSO)
Polydatin (CAS 27208-80-6) is a naturally occurring stilbenoid isolated primarily from the roots of Polygonum cuspidatum Structurally it represents the glucoside derivative of resveratrol exerting antioxidant and anti-inflammatory effects through modulation of oxidative stress-related pathways Research indicates that polydatin influences signaling cascades such as NF- B MAPK and Nrf2 contributing to its protective roles in cellular injury models including cardiovascular dysfunction neurodegeneration and inflammatory conditions Polydatin is soluble in methanol ethanol and acetone and stability is maintained by storage under sealed cool dry conditions
Apexbio Technology LLC BQU57 1637739-82-2 10mM (in 1mL DMSO)
BQU57 (CAS 1637739-82-2) is a small-molecule inhibitor derived from RBC8 selectively targeting the GDP-bound form of the Ral GTPases BQU57 binds preferentially to RalB-GDP exhibiting measured dissociation constants (Kd) of approximately 7 7 M (ITC) and 4 7 M (SPR) In vitro assays using cell lines such as H2122 and H358 have shown suppression of Ral-dependent anchorage-independent colony formation at IC50 values of 2 0 M and 1 3 M respectively In mouse xenograft tumor models administration of BQU57 resulted in reduced activation of RalA and RalB without affecting Ras or RhoA signaling highlighting its utility as a tool compound for investigating Ral-driven tumor biology
Apexbio Technology LLC P005091 882257-11-6 10mM (in 1mL DMSO)
P005091 (CAS 882257-11-6) is an inhibitor that selectively targets the ubiquitin-specific protease 7 (USP7) also known as herpes-associated ubiquitin-specific protease (HAUSP) By blocking USP7-mediated deubiquitination P005091 promotes degradation of HDM2 resulting in altered regulation of downstream targets including increased cellular levels of tumor suppressor proteins p53 and p21 Through USP7 inhibition P005091 can downregulate claspin and suppress phosphorylation of DNA checkpoint kinase Chk1 enhancing genotoxic drug sensitivity and inducing apoptosis in cancer cell lines irrespective of p53 mutational status This makes P005091 relevant as a research probe for studying USP7-dependent signaling pathways and cancer cell biology
Apexbio Technology LLC Piceatannol 10083-24-6 10mM (in 1mL DMSO)
Piceatannol (CAS 10083-24-6) is a naturally occurring small molecule exhibiting anti-inflammatory immunomodulatory and antiproliferative activities It functions primarily by inhibiting protein tyrosine kinases including p56lck and syk kinases and suppressing tumor necrosis factor (TNF)-induced nuclear factor-kappa B (NF- B) activation and downstream gene expression Biologically piceatannol arises as a metabolite of resveratrol through oxidation by cytochrome P450 1B1 This compound is employed in biomedical research to explore kinase signaling pathways inflammatory response regulation and potential therapeutic interventions
Apexbio Technology LLC Dioscin 19057-60-4 10mM (in 1mL DMSO)
Dioscin (CAS 19057-60-4) is a steroidal saponin isolated primarily from Dioscorea nipponica Makino Structurally it belongs to glycosidic steroid derivatives known for modulating various biological pathways Dioscin exerts bioactivity predominantly through regulation of cellular signaling cascades such as apoptosis induction anti-inflammatory responses and oxidative stress reduction Studies suggest that dioscin interacts with signaling pathways including PI3K/Akt ERK/MAPK and NF- B Due to these activities dioscin is commonly investigated for its potential anti-inflammatory anticancer and antioxidant effects making it relevant for biomedical research focused on chronic inflammation and cancer therapeutics
Apexbio Technology LLC MK-8745 885325-71-3 10mM (in 1mL DMSO)
MK-8745 (CAS 885325-71-3) is a small-molecule inhibitor targeting Aurora A kinase a serine/threonine kinase regulating chromosomal segregation during mitosis Aberrant Aurora A activity correlates with cancer progression In preclinical studies MK-8745 suppresses Aurora A kinase eliciting p53-dependent apoptosis and G2/M cell cycle arrest MK-8745 demonstrates antitumor activity in vitro across various cancer cell lines including p53-deficient and checkpoint-defective HCT116 variants and inhibits tumor growth in xenografted tumor models signifying its potential utility in cancer research targeting Aurora kinase pathways
Apexbio Technology LLC Enrofloxacin 93106-60-6 10mM (in 1mL DMSO)
Enrofloxacin a fluoroquinolone antibiotic exerts antibacterial activity by inhibiting bacterial DNA gyrase and topoisomerase IV enzymes essential for DNA replication and transcription This mechanism disrupts the DNA synthesis of pathogenic bacteria resulting in bacteriostatic outcomes In vitro experiments indicate that Enrofloxacin displays antimicrobial activity against Mycoplasma species such as Mycoplasma bovis with a minimum inhibitory concentration (MIC90) around 0 312 g/mL In biomedical research this compound is primarily utilized to establish microbial infection models and to study bacterial resistance mechanisms pharmaceutical efficacy and antibacterial pharmacodynamics
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide, 67-68-5, MFCD00002089, 5x10mL
Linear Formula (CH3)2SO, Molecular Weight 78.13, BioPerformance Certified, suitable for hybridoma, Ready-to-use sterile filtered product conveniently packaged in septum screw-capped amber bottles. Meets USP and EP testing requirements.
