Dimethyl Sulfoxide
Apexbio Technology LLC LY2157299(Synonyms: Galunisertib, LY-2157299, LY2157299 monohydrate, LY2157299 hydrate, LY2157299 free base), 10mM (in 1mL DMSO), CAS: 700874-72-2.
LY2157299 (CAS 700874-72-2) is a small-molecule antagonist that selectively targets the transforming growth factor-beta type I receptor (T RI) By blocking signaling through T RI it prevents phosphorylation of downstream effectors Smad2 and Smad3 thereby interfering with the TGF- signaling pathway Preclinical studies indicate LY2157299 inhibits 1-integrin activation reduces tumor cell invasion lowers connective tissue growth factor (CTGF) production and suppresses angiogenesis Currently in phase II clinical trials LY2157299 is being investigated primarily for therapeutic potential against hepatocellular carcinoma and glioblastoma
Medchemexpress LLC Arachidonic Acid-10Mm-1Ml Dmso | HY-109590-10MM-1ML DMSO
Arachidonic Acid-10Mm-1Ml Dmso
Gold Biotechnology Inc DMSO ACS Grade 100 mL
Dimethylsulfoxide (DMSO) is a very polar organic compound that is useful in organic chemistry for solubilizing organic and inorganic compounds DMSO is also used as a cryoprotectant for cell media preventing the formation of ice crystals which would otherwise damage cells DMSO can be used in PCR reactions to inhibit the self-complementation of DNA or PCR primers and increase amplification especially for DNA sequences which have GC rich sequences
Apexbio Technology LLC GSK1904529A 1089283-49-7 10mM (in 1mL DMSO)
GSK1904529A (CAS 1089283-49-7) is a small-molecule inhibitor targeting insulin-like growth factor-I receptor (IGF-1R) Mechanistically it acts as a reversible ATP-competitive antagonist inhibiting IGF-1R kinase activity with an IC50 of approximately 27 nM and a Ki value of 1 6 nM In NIH-3T3/LISN cells it reduces IGF-1R phosphorylation at an IC50 of about 22 nM subsequently attenuating phosphorylation of downstream effectors such as AKT IRS-1 and ERK pathways GSK1904529A also suppresses proliferation in various tumor cell lines through cell-cycle arrest at the G1 phase and demonstrates tumor growth inhibition in xenograft mouse models It serves as a research tool for investigating IGF-1R signaling in oncology
Medchemexpress LLC ML-792 | CAS No. : 1644342-14-2 | 10 mM * 1 mL in DMSO
ML-792 is a potent and selective inhibitor of SAE/SUMO1 and SAE/SUMO2 in enzymatic assays (IC50 values of 3 and 11 nM, respectively) compared with NAE/NEDD8 and UAE/ubiquitin (IC50> values of 32 μM and >100 μM, respectively).
Apexbio Technology LLC Afatinib (BIBW2992) 439081-18-2 10mM (in 1mL DMSO)
Afatinib (BIBW2992 CAS 439081-18-2) is an irreversible inhibitor targeting receptor tyrosine kinases in the ErbB protein family specifically EGFR (ErbB1) and HER2 (ErbB2) By covalently binding to their kinase domains it suppresses downstream ErbB signaling showing demonstrated inhibition with IC50 values of 0 5 nM for EGFR and 14 nM for HER2 Afatinib blocks EGF-induced phosphorylation and cellular proliferation in multiple EGFR- or HER2-expressing lines including A431 NIH-3T3-HER2 NCI-N87 and BT-474 Research applications include tumor xenograft studies and transgenic lung cancer models evaluating EGFR-dependent oncogenic processes and therapeutic responses
Apexbio Technology LLC Busulfan 55-98-1 10mM (in 1mL DMSO)
Busulfan is a DNA alkylating agent widely used in biomedical research as an anticancer compound It functions by forming cross-links on guanine bases within DNA leading to DNA damage and subsequent inhibition of cell growth and proliferation In vitro studies reveal that exposure to busulfan (IC50 range approximately 7 5 120 M) promotes cellular senescence in normal human fibroblast cell lines mediated through increased reactive oxygen species (ROS) and sustained activation of MAPK signaling pathways Additionally busulfan is utilized in fertility and reproductive biology research due to its ability to induce apoptosis in male germ cells reducing germ cell populations in experimental mouse models
Apexbio Technology LLC Carbadox 6804-07-5 10mM (in 1mL DMSO)
Carbadox is an antibiotic compound employed in bacterial infection research primarily targeting pathogenic organisms associated with gastrointestinal infections in swine including swine dysentery Its antibacterial mechanism involves inhibition of bacterial DNA synthesis and disruption of nucleic acid metabolism thereby interfering with pathogen replication Carbadox is frequently utilized in microbiology studies investigating therapeutic interventions against enteric bacterial pathogens under controlled laboratory conditions In vitro studies report Carbadox demonstrating bacteriostatic activity with IC50 values typically ranging between 0 5 2 g/mL for common susceptible bacterial strains serving as a reference substance in microbial sensitivity assays
Apexbio Technology LLC Simvastatin (Zocor) 79902-63-9 10mM (in 1mL DMSO)
Simvastatin (CAS 79902-63-9) marketed as Zocor is a synthetic lactone derived from fermented Aspergillus terreus metabolites Following oral administration the inactive lactone is hydrolyzed into an active -hydroxy acid metabolite which specifically inhibits HMG-CoA reductase the rate-limiting enzyme in cholesterol biosynthesis Simvastatin demonstrates antiproliferative effects in hepatocellular carcinoma cells (HepG2 Huh7) inducing apoptosis cell cycle arrest at G0/G1 reducing expression of cyclins (D1 E) and cyclin-dependent kinases (CDK1 2 4) while elevating CDK inhibitors p19 and p27 It is therefore utilized extensively for research in cancer biology cardiovascular pathology and lipid metabolism disorders
Apexbio Technology LLC Nanaomycin A 52934-83-5 10mM (in 1mL DMSO)
Nanaomycin A is a selective inhibitor targeting DNA methyltransferase 3B (DNMT3B) with an IC50 of approximately 500 nM It acts by specifically inhibiting DNMT3B-mediated DNA methylation without notably affecting DNMT1 activity In cell-based studies employing cancer cell lines such as HCT116 A549 and HL60 treatment with Nanaomycin A reduced global DNA methylation levels and reactivated transcription of tumor suppressor genes previously silenced via promoter hypermethylation Its use in epigenetics-related research includes quantitative assessment of DNMT3B function investigation of DNA methylation regulation mechanisms and evaluation of gene reactivation consequent to DNMT3B inhibition
Apexbio Technology LLC JNJ-26481585 875320-29-9 10mM (in 1mL DMSO)
JNJ-26481585 (CAS 875320-29-9) is a small-molecule inhibitor targeting class I histone deacetylases (HDACs) specifically HDAC1 HDAC2 and HDAC3 with reported IC50 values of 0 11 0 33 and 4 8 nM respectively It exhibits potent anti-proliferative activity across various human cancer cell lines including lung breast colon prostate ovarian and brain cancers (IC50 range 3 1 246 nM) Mechanistically JNJ-26481585 induces histone H3 acetylation alleviates HDAC-mediated repression of the p21waf1 cip1 promoter and promotes apoptosis in colorectal cancer cell models Consequently this compound serves as a research tool for cancer epigenetics and therapeutic assessment
Apexbio Technology LLC Pracinostat (SB939) 929016-96-6 10mM (in 1mL DMSO)
Pracinostat (SB939 CAS 929016-96-6) is an orally bioavailable inhibitor of histone deacetylases (HDAC) preferentially targeting class I II and IV HDACs with substantially lower affinity for class III enzymes By inhibiting these enzymes pracinostat promotes accumulation of acetylated histone H3 and acetylated -tubulin subsequently upregulating cell cycle regulator p21 In preclinical investigations SB939 demonstrated antiproliferative activity in various tumor cell lines including colon ovarian prostate cancers acute myeloid leukemia (AML) and B-cell lymphoma highlighting its potential utility in oncology research